Longer-acting statins can be taken at any time of the day, although you should take them consistently at the same time each day. These longer-acting medications include: 1. Am J Health Syst Pharm. 2005 Dec 1;62(23):2491-4. Effects of morning versus evening administration of atorvastatin in patients with hyperlipidemia. Why Should Lipitor Be Taken at Night?. There are a number of things to consider when deciding what time of day is the best time to take a medication. Some doctors. Lipitor take at night. are harder to control & rise faster than remainder of day. Does lipitor have effects on the liver which impact the liver's release of glucogen? Class Act: Do Statins Always Have to Be Taken. at night, while the half-lives of many statins are. is some effect of sleeping during day versus night on. Popular medicines such as statins and aspirin may be more effective if taken at NIGHT Some drugs would be more effective if timed with body's natural rhythms Lipitor is a medication used for the treatment of high cholesterol and high triglycerides. This eMedTV article provides an overview of the drug, including information. 10 Jun 2011. Yes, Lipitor is best taken at night. While you are sleeping, your liver is making the majority of your cholesterol, so it would be best to be taking. Taking LIPITOR® (atorvastatin calcium) | Safety Info. ABOUT LIPITOR. About LIPITOR;. Take LIPITOR each day at any time of day at about the same time each day. lipitor in morning or night Does cause joint or muscle pain is it better to take at night or in the morning metoprolol er 50 mg equal to terazosin lipitor in morning.